In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …

Summary Poly (A)(pA) tail binding proteins (PABPs) control mRNA polyadenylation, stability,
and translation. In a purified system, S. cerevisiae PABPs, Pab1p and Nab2p, are …

Beyond the well-known function of poly (A) tail length in mRNA stability, recent years have
witnessed an explosion of information about how changes in tail length and the selection of …

Poly (A) tails are important elements in mRNA translation and stability, although recent
genome-wide studies have concluded that poly (A) tail length is generally not associated …

A poly (A) tail functions in mRNA turnover and in facilitating translation as a
ribonucleoprotein complex with poly (A) binding proteins (PABPs). However, factors that …

While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …

Poly (A) tails are important regulators of mRNA stability and translational efficiency.
Cytoplasmic removal of poly (A) tails by 3′→ 5′ exonucleases (deadenylation) is the rate …

The polyadenosine tail (poly [A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …

Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …