Airway submucosal gland serous cells are important sites of fluid secretion in conducting
airways. Serous cells also express the cystic fibrosis (CF) transmembrane conductance …

The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Cytoplasmic Ca 2+ is a master regulator of airway physiology; it controls fluid, mucus, and
antimicrobial peptide secretion, ciliary beating, and smooth muscle contraction. The focus of …

Mucociliary clearance, driven by the engine of ciliary beating, is the primary physical airway
defense against inhaled pathogens and irritants. A better understanding of the regulation of …

Protease-activated receptor 2 (PAR2), a G protein-coupled receptor expressed in airway
epithelia and smooth muscle, plays an important role in airway inflammation. In this study …

Airway submucosal glands contribute to airway surface liquid (ASL) composition and
volume, both important for lung mucociliary clearance. Serous acini generate most of the …

Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

Physical stimulation of airway surfaces evokes liquid secretion, but the events that mediate
this vital protective function are not understood. When cystic fibrosis transmembrane …

Protease‐activated receptors (PARs) are widely distributed in human airways. They couple
to G‐proteins and are activated after proteolytic cleavage of the N terminus of the receptor …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …