The most common mutation in the CFTR gene in individuals with cystic fibrosis (CF), ΔF508,
leads to the absence of CFTR Cl− channels in the apical plasma membrane, which in turn …

Airway epithelia are confronted with distinct signals emanating from the luminal and/or
serosal environments. This study tested whether airway epithelia exhibit polarized …

Extracellular ATP and its metabolite adenosine regulate mucociliary clearance in airway
epithelia. Little has been known, however, regarding the actual ATP and adenosine …

In cystic fibrosis (CF) airways, abnormal epithelial ion transport likely initiates mucus stasis,
resulting in persistent airway infections and chronic inflammation. Mucus clearance is …

The mucosa of the proximal airways defends itself and the lower airways from inhaled
irritants such as capsaicinoids, allergens, and infections by several mechanisms. Sensory …

We evaluated the relationship between apical surface fluid (ASF) and protein secretion in
Calu-3 cells grown at an air–liquid interface. Calu-3 monolayers responded to forskolin, a …

The airway is kept sterile by an efficient innate defense mechanism. The cornerstone of
airway defense is mucus containing diverse antimicrobial factors that kill or inactivate …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …

We examined the mechanisms underlying anion secretion mediated by protease‐activated
receptor 2 (PAR2) and its role in the regulation of ion transport, using polarized human …

Airway surface liquid (ASL) absorption is initiated by Na+ entry via epithelial Na+ channels
(ENaC), which establishes an osmotic gradient that drives fluid from the luminal to serosal …