Overview of the 2022 WHO classification of neuroendocrine neoplasms

G Rindi, O Mete, S Uccella, O Basturk, S La Rosa… - Endocrine …, 2022 - Springer
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …

G Rindi, DS Klimstra, B Abedi-Ardekani, SL Asa… - Modern Pathology, 2018 - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

[HTML][HTML] Nothing but NET: a review of neuroendocrine tumors and carcinomas

B Oronsky, PC Ma, D Morgensztern, CA Carter - Neoplasia, 2017 - Elsevier
This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare
and heterogeneous tumor type, comprising~ 2% of all malignancies, with a prevalence of< …

Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging

DS Klimstra - Seminars in oncology, 2013 - Elsevier
Much recent debate has focused on the optimal classification of epithelial neuroendocrine
tumors (NETs). Multiple different systems of terminology, grading, and staging have been …

[HTML][HTML] The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

J van Riet, HJG van de Werken, E Cuppen… - Nature …, 2021 - nature.com
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems

DS Klimstra, IR Modlin, D Coppola, RV Lloyd, S Suster - Pancreas, 2010 - journals.lww.com
Neuroendocrine tumors (NETs) arise in most organs of the body and share many common
pathologic features. However, a variety of different organ-specific systems have been …

[HTML][HTML] Neuroendocrine neoplasm update: toward universal nomenclature

G Rindi, F Inzani - Endocrine-related cancer, 2020 - erc.bioscientifica.com
Neuroendocrine neoplasia is described in almost every tissue, either in the pure endocrine
organs, the nerve structures or in the so-called diffuse neuroendocrine system. The current …

Neuroendocrine tumor heterogeneity adds uncertainty to the World Health Organization 2010 Classification: real‐world data from the Spanish Tumor Registry (R …

B Nuñez‐Valdovinos, A Carmona‐Bayonas… - The …, 2018 - academic.oup.com
Background Gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are a
complex family of tumors of widely variable clinical behavior. The World Health Organization …

Neuroendocrine neoplasms: dichotomy, origin and classifications

G Klöppel - Visceral medicine, 2017 - karger.com
Neuroendocrine neoplasms (NENs) are heterogeneous tumors with a common phenotype.
There are two fundamentally different groups of NENs: well-differentiated, low-proliferating …

[HTML][HTML] Classification of neuroendocrine neoplasms: lights and shadows

S La Rosa, S Uccella - Reviews in endocrine and metabolic disorders, 2021 - Springer
Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations
showing different morphological features, immunophenotype, molecular background …