Living virus‐based nanohybrids for biomedical applications

L Jin, Z Mao - Wiley Interdisciplinary Reviews: Nanomedicine …, 2024 - Wiley Online Library
Living viruses characterized by distinctive biological functions including specific targeting,
gene invasion, immune modulation, and so forth have been receiving intensive attention …

[HTML][HTML] Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …

Rational design of virus-like particles for nanomedicine

W Shan, C Wang, H Chen, L Ren - Accounts of Materials …, 2023 - ACS Publications
Conspectus With a plethora of advances in nanotechnology and biotechnology, the
development of natural particle-based drug delivery vectors is a rapidly emerging field; …

Virion‐like membrane‐breaking nanoparticles with tumor‐activated cell‐and‐tissue dual‐penetration conquer impermeable cancer

X Zhang, X Xu, Y Li, C Hu, Z Zhang, Z Gu - Advanced Materials, 2018 - Wiley Online Library
Poor drug penetration into tumor cells and tissues is a worldwide difficulty in cancer therapy.
A strategy is developed for virion‐like membrane‐breaking nanoparticles (MBNs) to …

Intracellular delivery of virus-like particles using a sheddable linker

LM Hagge, A Shahrivarkevishahi… - Journal of Materials …, 2023 - pubs.rsc.org
Intracellular targeting is essential for the efficient delivery of drugs and nanotherapeutics.
Transporting nanomaterials into cells' cytoplasm for therapeutic purposes can be …

Viral mimicking ternary polyplexes: a reduction‐controlled hierarchical unpacking vector for gene delivery

Y He, Y Nie, G Cheng, L Xie, Y Shen… - Advanced Materials, 2014 - Wiley Online Library
With millions of years of evolution, viruses are powerful natural masterpieces for efficient
heterogenome invasion via sophisticated mechanisms.[1] Most viruses are nanoscale …

[HTML][HTML] Morphological and constituent viral-mimicking self-assembled nanoparticles promote cellular uptake and improve cancer therapeutic efficiency in vivo

W Zhang, Z Zhai, S Huang, Z Mao, Y Zhang, C Gao - Giant, 2020 - Elsevier
The delivery of nanomaterials or therapeutics into cells takes a decisive role for their
applications in nanomedicine. Nature's creations such as viruses provide valued inspiration …

[HTML][HTML] Current progress of virus-mimicking nanocarriers for drug delivery

M Somiya, Q Liu, S Kuroda - Nanotheranostics, 2017 - ncbi.nlm.nih.gov
Nanomedicines often involve the use of nanocarriers as a delivery system for drugs or
genes for maximizing the therapeutic effect and/or minimizing the adverse effect. From drug …

Highly modular hepatitis B virus-like nanocarriers for therapeutic protein encapsulation and targeted delivery to triple negative breast cancer cells

D Yur, MO Sullivan, W Chen - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Protein therapeutics offer enormous clinical impact in treating a variety of diseases by
offering high selectivity with limited off-target effects. However, delivery challenges severely …

Virus-mimetic nanovesicles as a versatile antigen-delivery system

P Zhang, Y Chen, Y Zeng, C Shen… - Proceedings of the …, 2015 - National Acad Sciences
It is a critically important challenge to rapidly design effective vaccines to reduce the
morbidity and mortality of unexpected pandemics. Inspired from the way that most …