Friendly fungi: symbiosis with commensal Candida albicans

TY Shao, DB Haslam, RJ Bennett, SS Way - Trends in immunology, 2022 - cell.com
Mucosal tissues are constitutively colonized by a wide assortment of host-adapted microbes.
This includes the polymorphic fungus Candida albicans which is a primary target of human …

New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

A Pellon, SD Sadeghi Nasab… - Frontiers in cellular and …, 2020 - frontiersin.org
The mucosal surfaces of the human body are challenged by millions of microbes on a daily
basis. Co-evolution with these microbes has led to the development of plastic mechanisms …

Candida innate immunity at the mucosa

JP Richardson, DL Moyes, J Ho, JR Naglik - Seminars in Cell & …, 2019 - Elsevier
The tremendous diversity in microbial species that colonise the mucosal surfaces of the
human body is only now beginning to be fully appreciated. Distinguishing between the …

Innate Immunity to Mucosal Candida Infections

A Verma, SL Gaffen, M Swidergall - Journal of Fungi, 2017 - mdpi.com
Mucosal epithelial tissues are exposed to high numbers of microbes, including commensal
fungi, and are able to distinguish between those that are avirulent and those that cause …

[HTML][HTML] Immunosurveillance of Candida albicans commensalism by the adaptive immune system

M Swidergall, S LeibundGut-Landmann - Mucosal immunology, 2022 - Elsevier
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing
the body surfaces and is involved in many key aspects of human physiology, while an …

Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression

FR Kirchner, K Littringer, S Altmeier, VDT Tran… - Frontiers in …, 2019 - frontiersin.org
Controlled immune activation in response to commensal microbes is critical for the
maintenance of stable colonization and prevention of microbial overgrowth on epithelial …

Interplay between Candida albicans and the mammalian innate host defense

SC Cheng, LAB Joosten, BJ Kullberg… - Infection and …, 2012 - Am Soc Microbiol
Candida albicans is both the most common fungal commensal microorganism in healthy
individuals and the major fungal pathogen causing high mortality in at-risk populations …

Immune interactions with pathogenic and commensal fungi: a two-way street

DM Underhill, E Pearlman - Immunity, 2015 - cell.com
We are exposed to a wide spectrum of fungi including innocuous environmental organisms,
opportunistic pathogens, commensal organisms, and fungi that can actively and explicitly …

[HTML][HTML] “Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease

MW Gutierrez, E van Tilburg Bernardes… - Mucosal …, 2022 - Elsevier
Fungi are important yet understudied contributors to the microbial communities of the
gastrointestinal tract. Starting at birth, the intestinal mycobiome undergoes a period of …

Candida albicans dwelling in the mammalian gut

JC Pérez - Current opinion in microbiology, 2019 - Elsevier
The yeast Candida albicans inhabits the gastrointestinal tract of most healthy adults,
seemingly living there as a harmless commensal. The fungus on occasion disseminates …