Abstract Background and Objective Pharmacokinetics (PK) are severely altered in pregnant
women due to changes in volume of distribution (Vd) and/or drug clearance (CL), affecting …

Introduction Understanding the pharmacokinetics (PK) of antimicrobial drugs in pregnant
women is crucial to provide effective and safe treatment. This study is part of a series that …

Purpose: Antibiotics are commonly used during pregnancy. However, physiological changes
during pregnancy can affect the pharmacokinetics of drugs, including antibiotics, used …

The aim of the antibacterial therapy during pregnancy is to select a proper antibiotic and
determine its effective dose, at the same time excluding the risk of potential teratogenic …

Few of the articles published on antibiotics and pregnancy are concerned with
pharmacokinetics. It is particularly difficult to evaluate possible alterations in …

Summary β-Lactam antibiotics represent the oldest class of antibiotics used in the treatment
of infections, and benzylpenicillin (penicillin G) is still the most commonly used antibiotic …

During pregnancy, untreated sexually transmitted or urinary tract infections are associated
with significant morbidity, including low birth weight, preterm birth, and spontaneous …

Dosage schedules for antibotics should be based upon pharmacokinetic studies. Such
studies provide knowledge about serum, tissue, and urine levels which may be obtained in a …

Pregnancy is associated with special problems with respect to antibiotic selection and
dosage due to potential teratogenic or toxic effects on the fetus by the drug itself, and the …

Pregnant women and their unborn fetuses are a population with unique and heightened
risks from a variety of infectious conditions. Sizable percentages of pregnant women receive …