Muscle wasting disease indications are among the most debilitating and often deadly
noncommunicable disease states. As a comorbidity, muscle wasting is associated with …

Over the past 25 years, considerable progress has been made in terms of elucidating the
regulatory and signaling mechanisms underlying the control of skeletal muscle mass by …

Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Myostatin, a member of the transforming growth factor beta (TGF‐β) superfamily that is
highly expressed in skeletal muscle, was first described in 1997. It has been known that loss …

Myostatin is a secreted protein that normally functions as a negative regulator of muscle
growth. Agents capable of blocking the myostatin signaling pathway could have important …

Background Loss of skeletal muscle mass and function in humans is associated with
significant morbidity and mortality. The role of myostatin as a key negative regulator of …

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Muscle wasting increases the risks of morbidity and mortality. But, the reliability of estimates
of the degree of muscle wasting is controversial as are definitions of terms like cachexia …

Muscle regeneration through myostatin inhibition : Current Opinion in Rheumatology Muscle
regeneration through myostatin inhibition : Current Opinion in Rheumatology Log in or Register …

Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass
and quality, decreased power and strength, increased risk of injury from falls, and often …