Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

The presence of sufficient skeletal muscle is of paramount importance for body function.
Cachexia can be defined as a wasting syndrome describing the progressive loss of both …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

Skeletal muscle fibrosis is a defining feature of the muscular dystrophies in which contractile
myofibers are replaced by fibroblasts, adipocytes and extracellular matrix. This maladaptive …

The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …

Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …

Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic
metabolism. Exercise and blocking of myostatin/activin signaling may independently or …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Inhibition of the myostatin signaling pathway is emerging as a promising therapeutic means
to treat muscle wasting and degenerative disorders. Activin type IIB receptor (ActRIIB) is the …