The application of 3D X-ray imaging for biological samples (eg biopsies) to gain a deeper
understanding of microscopic structures on a (sub) cellular level is restricted by the weak …

Many histological methods require staining of the cytoplasm, which provides instrumental
details for diagnosis. One major limitation is the production of 2D images obtained by …

We demonstrate a laboratory-based method combining X-ray microCT and nanoCT with a
specific X-ray stain, which targets the cell cytoplasm. The described protocol is easy to …

Histological investigations are indispensable with regards to the identification of structural
tissue details but are limited to two-dimensional images, which are often visualized in one …

Recent developments within micro-computed tomography (μCT) imaging have combined to
extend our capacity to image tissue in three (3D) and four (4D) dimensions at micron and …

Historically, micro-computed tomography (μCT) has been considered unsuitable for
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …

Low inherent contrast in soft tissues has been limiting the use of X-ray absorption micro-
computed tomography (micro-CT) to access high-resolution structural information of animal …

For fully characterizing renal cell carcinoma (RCC), information about the 3D tissue
microstructure is essential. Histopathology, which represents the current diagnostic gold …

Background The University of Southampton, in collaboration with the University Hospital
Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront …

Since its initial development and demonstration by GN Hounsfield in the early 1970's [1, 2],
X-ray computed tomography (XCT) has proven to be an important imaging tool for a variety …