BAFF and selection of autoreactive B cells

Z Liu, A Davidson - Trends in immunology, 2011 - cell.com
B cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells,
and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF …

The rationale for BAFF inhibition in systemic lupus erythematosus

A Davidson - Current rheumatology reports, 2012 - Springer
BAFF (B-cell–activating factor) is a critical survival factor for transitional and mature B cells
and is a promising therapeutic target for systemic lupus erythematosus (SLE). In 2010–2011 …

BAFF inhibition in SLE—Is tolerance restored?

SW Jackson, A Davidson - Immunological reviews, 2019 - Wiley Online Library
The B cell activating factor (BAFF) inhibitor, belimumab, is the first biologic drug approved for
the treatment of SLE, and exhibits modest, but durable, efficacy in decreasing disease flares …

Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus

W Stohl - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: The B-cell activating factor (BAFF) axis comprises two ligands (BAFF and
APRIL) and three receptors (BCMA, TACI, BR3). BAFF is a vital B-cell survival factor and …

The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

FB Vincent, D Saulep-Easton, WA Figgett… - Cytokine & growth factor …, 2013 - Elsevier
The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling

F Mackay, PA Silveira, R Brink - Current opinion in immunology, 2007 - Elsevier
B-cell activation factor from the tumor necrosis factor family (BAFF) is a key survival factor
during B-cell maturation—a delicate immune checkpoint for B cells. Excessive BAFF …

Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases

E Samy, S Wax, B Huard, H Hess… - International reviews of …, 2017 - Taylor & Francis
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

FB Vincent, EF Morand… - Immunology and cell …, 2012 - Wiley Online Library
Recently, the B cell has emerged as a cornerstone of systemic lupus erythematosus (SLE)
pathogenesis. This has been highlighted by studies of the cytokine B‐cell‐activating factor of …

B cell activating factor (BAFF): structure, functions, autoimmunity and clinical implications in systemic lupus erythematosus (SLE)

T Möckel, F Basta, J Weinmann-Menke… - Autoimmunity reviews, 2021 - Elsevier
The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival
factor which supports autoreactive B cells and prevents their deletion. BAFF expression is …

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

WA Figgett, D Deliyanti, KA Fairfax, PS Quah… - Journal of …, 2015 - Elsevier
B cell-activating factor of the TNF family (BAFF) is an essential B cell survival factor.
However, high levels of BAFF promote systemic lupus erythematosus (SLE) in mice and …