Systemic lupus erythematosus (SLE) is a complex immune disorder in which loss of
tolerance to nucleic acid antigens and other cross‐reactive antigens is associated with the …

BAFF (BLyS) and APRIL are TNF-like cytokines that support survival and differentiation of B
cells. Recent studies have discovered a role for BAFF in augmenting both innate and …

B cells play a pivotal role in autoimmunity not only by producing pathogenic autoantibodies
but also by modulating immune responses via the production of cytokines and chemokines …

It is increasingly recognized that B cells have multiple functions that contribute to the
pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate …

Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, which
exhibits multiple B cell abnormalities including expanded populations of memory B cells and …

B cells have multiple roles in immune activation and inflammation separate from their
capacity to produce antibodies. B cell depletion is currently under intense investigation as a …

For the first time in more than 50 years, the US Food and Drug Administration has approved
a drug specifically for the treatment of systemic lupus erythematosus (SLE). This drug …

B cell activating factor of the TNF family (BAFF, also known as BLyS), a cytokine that
regulates homeostasis of peripheral B cells, is elevated in the circulation of patients with …

Autoimmune rheumatic disorders have complex etiopathogenetic mechanisms in which B
cells play a central role. The importance of factors stimulating B cells, notably the B-cell …

Objective To understand the effects of long‐term BLyS inhibition in human systemic lupus
erythematosus (SLE). Methods Seventeen patients with SLE who were enrolled in a clinical …