Neuroblastoma (NB) is a highly malignant pediatric solid tumor where a hypoxic signature
correlates with unfavorable patient outcome. The hypoxia-inducible factor (HIF)-1α plays an …

Neuroblastoma (NB) is a highly malignant pediatric solid tumor where a hypoxic signature
correlates with unfavorable patient outcome. The hypoxia‐inducible factor (HIF)‐1α plays an …

Hypoxia occurs in physiological and pathological conditions. T cells experience hypoxia in
pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia …

Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in
humans, with a uniformly poor prognosis. Hypoxia is a predominant feature in GBM and its …

The high aggressiveness of gliomas remains a huge challenge to clinical therapies, and the
hypoxic microenvironment in the core region is a critical contributor to glioma …

Previous studies have suggested that hypoxic responses are regulated by hypoxia-inducible
factors (HIFs), which in turn promote the malignant progression of glioblastoma (GBM) by …

Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

The brain tumor microenvironment has recently become a major challenge in all pediatric
cancers, but especially in brain tumors like high-grade gliomas. Hypoxia is one of the …

Hypoxic conditions regulate several metabolic enzymes and transcription factors that are
involved in cancer, ischemia and pulmonary diseases. The Ras homolog (Rho) family …

Purpose Several oxygen-dependent factors, eg, CAIX (carbonic anhydrase IX) or
phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine …