Ubiquitin-mediated protein degradation is the primary biological process by which protein
abundance is regulated and protein homeostasis is maintained in eukaryotic cells. Speckle …

The dysregulation of ubiquitin‐mediated proteasomal degradation has emerged as an
important mechanism of pathogenesis in several cancers. The speckle‐type POZ protein …

Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1
E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial …

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is a cullin 3-based E3
ubiquitin ligase adaptor protein that plays a crucial role in ubiquitin-mediated protein …

The initiation and progression of cancer is dependent on the acquisition of mutations in
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …

The SPOP gene, which encodes an E3 ubiquitin ligase adaptor, is frequently mutated in a
number of cancer types. However, the mechanisms by which SPOP functions as a tumor …

Abstract Steroid receptor co-activator-3 (SRC-3/AIB1) is an oncogene that is amplified and
overexpressed in many human cancers. However, the molecular mechanisms that regulate …

In the cytoplasm of virtually all clear-cell renal cell carcinoma (ccRCC), speckle-type POZ
protein (SPOP) is overexpressed and misallocated, which may induce proliferation and …

Speckle-type POZ domain protein (SPOP), an adaptor in the E3 ubiquitin ligase complex,
recognizes substrates and promotes protein degradation via the ubiquitin-proteasome …