Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Alzheimer's disease (AD) is the most common cause of cognitive impairment in older
patients, and its prevalence is expected to soar in coming decades. Neuropathologically, AD …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to …

Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …

The locus coeruleus (LC) is the noradrenaline (norepinephrine, NE)-containing nucleus in
the brainstem and innervates into widespread brain regions. This LC-NE system plays a …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

Catecholamine neurons of the locus coeruleus (LC) in the dorsal pontine tegmentum
innervate the entire neuroaxis, with signaling actions implicated in the regulation of …

The locus coeruleus (LC) is the brain's major source of the neuromodulator norepinephrine,
and is also profoundly vulnerable to the development of Alzheimer's disease (AD)-related …