Highlights•Changes in the microenvironment (TME) promote drug resistance.•Cellular
composition, biochemical and-biophysical parameters create tissue-specific TME.•Targeting …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years,
however, acquired resistance has emerged as a daunting challenge to anticancer …

Over the last decade, it has become clear that cancer is not just a disease of the genes, and
that the tumor microenvironment (TME) plays an important role in cancer progression …

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that
exist within and around the tumor mass. The TME is highly dynamic and its importance in …

This comprehensive review delves into the pivotal role of the tumor microenvironment (TME)
in cancer metastasis and therapeutic response, offering fresh insights into the intricate …

Tumor microenvironment (TME) is important in tumor development and may be a target for
anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Recent advances in cancer therapy encounter a bottleneck. Relapsing/recurrent disease
almost always developed eventually with resistance to the initially effective drugs. Tumor …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …