Altered metabolic programs and corruption of tissue architecture are hallmarks of disease.
The spatiotemporal control of cell behavior requires transmission of information from the …

All cells exist within the context of a three-dimensional microenvironment in which they are
exposed to mechanical and physical cues. These cues can be disrupted through …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the
cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell …

Much attention has been dedicated to understanding how cells sense and respond to
mechanical forces. The types of forces cells experience as well as the repertoire of cell …

In nearly all aspects of biology, forces are a relevant regulator of life's form and function.
More recently, science has established that cells are exquisitely sensitive to forces of varying …

Human cells encounter dynamic mechanical cues in healthy and diseased tissues, which
regulate their molecular and biophysical phenotype, including intracellular mechanics as …

The use of mechanical biology and biomechanical signal transduction is a novel approach
to attenuate biological tissue degeneration, whereas the understanding of specific cellular …

How do cells process environmental cues to make decisions? This simple question is still
generating much experimental and theoretical work, at the border of physics, chemistry and …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …