Mechanical forces play a fundamental role in cellular dynamics from the molecular level to
the establishment of complex heterogeneity in somatic and stem cells. Here, we highlight the …

The ability of cells to sense and respond to mechanical stimuli is crucial for many
developmental and homeostatic processes, while mechanical dysfunction of cells has been …

Cells have evolved sophisticated systems that integrate internal and external inputs to
coordinate cell shape changes during processes, such as development, cell identity …

Mechanotransduction-how cells sense physical forces and translate them into biochemical
and biological responses-is a vibrant and rapidly-progressing field, and is important for a …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

A cell embedded in a multicellular organism will experience a wide range of mechanical
stimuli over the course of its life. Fluid flows and neighboring cells actively exert stresses on …

External forces play complex roles in cell organization, fate, and homeostasis. Changes in
these forces, or how cells respond to them, can result in abnormal embryonic development …