Etiologically, 5% of all cancers worldwide are caused by the high-risk human
papillomaviruses (hrHPVs). These viruses encode two oncoproteins (E6 and E7) whose …

High-risk human papillomavirus (HPV) types 16 and 18 are associated with more than 70%
of cervical cancer cases. The oncoprotein E6 is multifunctional and has numerous cellular …

Invasive cervical cancer is very highly correlated with the presence of high-risk human
papillomavirus (HPV) types 16 and 18. Two viral proteins, E6 and E7, act in concert to …

Approximately 5% of cancers are caused by high-risk human papillomaviruses. Although
very effective preventive vaccines will reduce this cancer burden significantly over the next …

Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a
pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6–dependent p53 …

Cervical cancer is caused by a persistent infection of the mucosal epithelia with high-risk
human papilloma viruses (HPVs). The viral oncoprotein E6 is responsible for the inactivation …

Oncogenic types of human papillomaviruses (HPVs) are closely linked to the development
of anogenital and head and neck cancers. The expression of the viral E6 and E7 genes is …

The tumor suppressor p53 pathway, whose alterations are highly associated with all types of
human cancers, plays an essential role in preventing tumor development and progression …

The p53 tumor suppressor is regulated by the MDM2 oncoprotein through a negative
feedback mechanism. MDM2 promotes the ubiquitination and proteasome-dependent …

In a genome‑wide screen for microRNAs regulated by the transcription factor encoded by
the p53 tumor suppressor gene we found that after p53‑activation the abundance of thirty …