Abstract Dipeptidyl peptidase‐4 (DPP4) has been proven to exert its functions by both
enzymatic and nonenzymatic pathways. The nonenzymatic function of DPP4 in diabetes …

Objective: Inflammation, oxidative stress, and decreased glucagon-like peptide-1 (GLP-1)
are risk factors for cognitive impairment. Dipeptidyl peptidase-4 (DPP4) was identified as a …

OBJECTIVE Hyperglycemia, inflammation, and oxidative stress are thought to be involved in
the pathogenesis of cognitive decline. Dipeptidyl peptidase-4 (DPP4) is a newly identified …

Diabetic encephalopathy (DE) is a central nervous complication of diabetes mellitus which is
characterized by cognitive impairment and neurochemical abnormalities. However, no …

Background Impairment of regulatory T (Treg) cells function is implicated in the
pathogenesis of immune imbalance-mediated cognitive impairment. A complete …

Objectives: Diabetes is an independent risk factor for dementia. Mitochondrial dysfunction is
a critical player in diabetes and diabetic complications. The present study aimed to …

The linkage of neurodegenerative diseases with insulin resistance (IR) and type 2 diabetes
mellitus (T2DM), including oxidative stress, mitochondrial dysfunction, excessive …

Diabetes has adverse effects on the brain, especially the hippocampus, which is particularly
susceptible to synaptic injury and cognitive dysfunction. The underlying mechanisms and …

Dipeptidyl peptidase-4 (DPP-4) inhibitors have been considered as incretin-based agents
that signal through GLP-1R. Our high-throughput RNA sequencing (RNA-seq) and …

Prospective epidemiological studies suggest that type 2 diabetes is a risk factor for
neurodegenerative pathologies such as Alzheimer disease, vascular dementia, and …