Triplex-Forming Peptide Nucleic Acid Probes Having Cyanine Base Surrogates for Fluorogenic Sensing of Double-Stranded RNA

S Nishizawa, T Sato, ETT Lee, N Sakamoto… - Bunseki …, 2022 - tohoku.elsevierpure.com
Here we report on triplex-forming peptide nucleic acid (PNA) probes having thiazole orange
(TO) as a base surrogate for fluorogenic sensing of double stranded RNA (dsRNA) …

Triplex-forming peptide nucleic acid probe having thiazole orange as a base surrogate for fluorescence sensing of double-stranded RNA

T Sato, Y Sato, S Nishizawa - Journal of the American Chemical …, 2016 - ACS Publications
We have developed a new fluorescent sensing probe for double-stranded RNA (dsRNA) by
integrating thiazole orange (TO) as a base surrogate into triplex-forming PNA. Our probe …

Optimization of the Alkyl Linker of TO Base Surrogate in Triplex‐Forming PNA for Enhanced Binding to Double‐Stranded RNA

T Sato, Y Sato, S Nishizawa - Chemistry–A European Journal, 2017 - Wiley Online Library
A series of triplex‐forming peptide nucleic acid (TFP) probes carrying a thiazole orange (TO)
base surrogate through an alkyl linker was synthesized, and the interactions between these …

[HTML][HTML] Kinetic analysis of highly effective triplex formation between a small molecule–peptide nucleic acid conjugate probe and the influenza A virus RNA promoter …

CU Okeke, H Miura, Y Sato, S Nishizawa - Organic & Biomolecular …, 2023 - pubs.rsc.org
In order to overcome the pH limitations of triplex-forming peptide nucleic acid (PNA) in
binding to double-stranded RNA (dsRNA), we have recently proposed a new design of …

Red-emissive triplex-forming PNA probes carrying cyanine base surrogates for fluorescence sensing of double-stranded RNA

T Chiba, T Sato, Y Sato, S Nishizawa - Organic & Biomolecular …, 2017 - pubs.rsc.org
Red-emissive triplex-forming PNA probes carrying cyanine base surrogates for fluorescence
sensing of double-stranded RNA - Organic & Biomolecular Chemistry (RSC Publishing) …

Correction to “Triplex-Forming Peptide Nucleic Acid Probe Having Thiazole Orange as a Base Surrogate for Fluorescence Sensing of Double-stranded RNA”

T Sato, Y Sato, S Nishizawa - Journal of the American Chemical …, 2017 - ACS Publications
Correction to “Triplex-Forming Peptide Nucleic Acid Probe Having Thiazole Orange as a Base
Surrogate for Fluorescence Sensing Page 1 Correction to “Triplex-Forming Peptide Nucleic …

Sequence-and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog

MS Krishna, DFK Toh, Z Meng, AAL Ong… - Analytical …, 2019 - ACS Publications
RNAs are emerging as important biomarkers and therapeutic targets. The strategy of directly
targeting double-stranded RNA (dsRNA) by triplex-formation is relatively underexplored …

Fluorescent 2‐Aminopyridine Nucleobases for Triplex‐Forming Peptide Nucleic Acids

SK Cheruiyot, E Rozners - ChemBioChem, 2016 - Wiley Online Library
Abstract Development of new fluorescent peptide nucleic acids (PNAs) is important for
fundamental research and practical applications. The goal of this study was the design of …

Design of fluorescent peptide nucleic acid probes carrying cyanine dyes for targeting double-stranded RNAs for analytical applications

Y Sato - Bulletin of the Chemical Society of Japan, 2020 - academic.oup.com
With the increasing knowledge about the diverse roles of RNAs within cells, much attention
has been paid to the development of RNA-binding fluorescent probes for the study of RNA …

Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method

LG Carrascosa, S Gómez-Montes, A Aviñó… - Nucleic acids …, 2012 - academic.oup.com
A novel biosensing approach for the label-free detection of nucleic acid sequences of short
and large lengths has been implemented, with special emphasis on targeting RNA …