Fluorescently labeled oligonucleotides are commonly employed as probes to detect specific
DNA or RNA sequences in homogeneous solution. Useful probes should experience strong …

Peptide nucleic acid (PNA) forms a triple helix with double‐stranded RNA (dsRNA)
stabilized by a hydrogen‐bonding zipper formed by PNA's backbone amides (N− H) …

Triplex-forming peptide nucleic acids (PNAs) require chemical modifications for efficient
sequence-specific recognition of DNA and RNA at physiological pH. Our research groups …

A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-
NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd …

Fluorescent reporters are highly sensitive, nonperturbing, and convenient probes for
biological studies. Current techniques for recognition of specific nucleic acid sequences …

Structured RNAs play a major role in a wide range of biological processes related to the
expression and regulation of gene products. In structured RNA, helical regions composed of …

In the development of orthogonal extra base pairs for expanding the genetic alphabet, we
created novel, unnatural base pairs between fluorophore and quencher nucleobase …

A combination of fluorophore and nucleobase through a π-conjugated rigid linker integrates
the base pairing and the fluorescence change into a single event. Such base discriminating …

Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA
sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT …

It has been known for several decades that guanine-rich nucleic acid sequences have a
propensity to fold into highly stable four-stranded structures in vitro in the presence of …