Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa)
in the past decade. Both common and rare genetic variants with effects on risk ranging from …

Established risk factors for prostate cancer include age, ethnicity, a family history of prostate
cancer or carrying a pathogenic germline variation in a prostate cancer predisposition gene …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Most criteria for genetic testing for prostate cancer susceptibility require a prior diagnosis of
prostate cancer, in particular cases with metastatic disease are selected. Advances in the …

Background The goal of precision medicine in prostate cancer (PCa) is to individualize the
treatment according to the patient's germline mutation status. PCa has a very high rate of …

BACKGROUND Prostate cancer (PCa) remains the most common solid malignancy in men,
and its prevalence makes understanding its heritability of paramount importance. To date …

Simple Summary In this study, we identified germline mutations that contribute to prostate
cancer development in men who have multiple relatives with prostate cancer (and other …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

Prostate cancer is a significant cause of cancer mortality. It has been well-established that
certain germline pathogenic variants confer both an increased risk of being diagnosed with …

Few genetic risk factors have been demonstrated to be specifically associated with
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …