Carbapenemase-producing Enterobacterales have become a severe public health concern
because of their rapidly transmissible resistance elements and limited treatment options …

Background It is often challenging to select appropriate combination therapies to treat
infections caused by carbapenem-resistant Enterobacterales (CRE) with high-level …

Objectives Imipenem/relebactam, an investigational β-lactam/β-lactamase inhibitor
combination for treatment of Gram-negative infections, and comparators including …

Objectives This study aimed to analyse the in vitro activity of dual combinations of
carbapenems against Klebsiella pneumoniae producing the main carbapenemase types …

Carbapenem-resistant Enterobacterales (CRE) are some of the most important pathogens
causing infections, which can be challenging to treat. We identified four bla IMP-carrying …

Background The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has
become a significant problem for global public health. Currently, treatments program is …

Objectives To investigate the antibacterial activity of the novel β-lactamase inhibitor BLI-489
combined with imipenem or meropenem against diverse carbapenemase-producing …

Abstract Background Carbapenemase-producing Enterobacterales (CPE) show rapid global
dissemination and pose a significant therapeutic challenge. This study aimed to characterize …

Purpose: Optimal treatment regimens are yet to be established for carbapenemase-
producing Enterobacteriaceae (CPE). We assessed the in vitro efficacy of meropenem …

The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a major
global public health threat. Rapid and accurate detection of pathogenic bacteria is essential …