DNA methylation, associated with gene or transposable element (TE) repression, plays a
key role in spermatogenesis. During germ cell development, their methylome is …

DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …

DNA methylation (DNAme) serves a stable gene regulatory function in somatic cells (1). In
the germ line and during early embryogenesis, however, DNAme undergoes global erasure …

Background Formation of haploid spermatozoa capable of fertilization requires proper
programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3 …

In the male germ line, sequence-specific methylation patterns are initially acquired
prenatally in diploid gonocytes and are further consolidated after birth during …

DNA methylation is one of the epigenetic marks and plays critically important functions
during spermatogenesis in mammals. DNA methylation is catalysed by DNA …

The acquisition of genomic methylation in the male germ line is initiated prenatally in diploid
gonocytes, while DNA methylation in the female germ line is initiated postnatally in growing …

DNA methylation is one of the major epigenetic mechanisms crucial for gene regulation and
genome stability. De novo DNA methyltransferase DNMT3C is required for silencing …

DNA methylation plays important roles during spermatogenesis. This mechanism includes
maintenance and de novo methylation which are catalysed by DNA methyltransferase …

A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA
methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs …