Early adverse environmental exposures during brain development are widespread risk
factors for the onset of severe mental disorders and strong and consistent predictors of …

Early adversity influences brain development and emerging behavioral phenotypes relevant
for psychiatric disorders. Understanding the effects of adversity before and after conception …

Different dimensions of adversity may affect mental health through distinct neurobiological
mechanisms, though current supporting evidence consists largely of cross-sectional …

Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

Background Childhood maltreatment is associated with lifelong psychiatric sequelae.
However, our understanding of neurobiological mechanisms responsible for this association …

Adversity exposure is a risk factor for psychopathology, which most frequently onsets during
adolescence, and prior research has demonstrated that alterations in cortico-limbic …

Adversity in early childhood exerts an enduring impact on mental and physical health,
academic achievement, lifetime productivity, and the probability of interfacing with the …

Background Extensive animal research has demonstrated the vulnerability of the brain to
early life stress (ELS) with consequences for emotional development and mental health …

Animal and human studies have shown that both early-life traumatic events and ongoing
stress episodes affect neurodevelopment, however, it remains unclear whether and how …

Background Much research has focused on the deleterious neurobiological effects of
childhood adversity that may underlie internalizing disorders. Although most youth show …