Three alveolar phenotypes govern lung function in murine ventilator-induced lung injury

BJ Smith, GS Roy, A Cleveland, C Mattson… - Frontiers in …, 2020 - frontiersin.org
Mechanical ventilation is an essential lifesaving therapy in acute respiratory distress
syndrome (ARDS) that may cause ventilator-induced lung injury (VILI) through a positive …

Alveolar dynamics during mechanical ventilation in the healthy and injured lung

J Grune, A Tabuchi, WM Kuebler - Intensive care medicine experimental, 2019 - Springer
Mechanical ventilation is a life-saving therapy in patients with acute respiratory distress
syndrome (ARDS). However, mechanical ventilation itself causes severe co-morbidities in …

Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury

CL Mattson, K Okamura, PS Hume… - American Journal of …, 2022 - journals.physiology.org
Supportive mechanical ventilation is a necessary lifesaving treatment for acute respiratory
distress syndrome (ARDS). This intervention often leads to injury exacerbation by ventilator …

Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury

KL Hamlington, BJ Smith, CM Dunn… - Respiratory physiology …, 2018 - Elsevier
Understanding how the mechanisms of ventilator-induced lung injury (VILI), namely
atelectrauma and volutrauma, contribute to the failure of the blood-gas barrier and …

Linking ventilator injury-induced leak across the blood-gas barrier to derangements in murine lung function

BJ Smith, E Bartolak-Suki, B Suki, GS Roy… - Frontiers in …, 2017 - frontiersin.org
Mechanical ventilation is vital to the management of acute respiratory distress syndrome, but
it frequently leads to ventilator-induced lung injury (VILI). Understanding the …

The physical basis of ventilator-induced lung injury

M Plataki, RD Hubmayr - Expert review of respiratory medicine, 2010 - Taylor & Francis
Although mechanical ventilation (MV) is a life-saving intervention for patients with acute
respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as …

Differential effects of two-hit models of acute and ventilator-induced lung injury on lung structure, function, and inflammation

J Bilodeaux, H Farooqi, M Osovskaya, A Sosa… - Frontiers in …, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) and acute lung injury have a diverse spectrum
of causative factors including sepsis, aspiration of gastric contents, and near drowning …

Altered alveolar mechanics in the acutely injured lung

HJ Schiller, UG McCann, DE Carney… - Critical care …, 2001 - journals.lww.com
Objectives Alterations in alveolar mechanics (ie, the dynamic change in alveolar size during
tidal ventilation) are thought to play a critical role in acute lung injuries such as acute …

Impact of ventilation-induced lung injury on the structure and function of lamellar bodies

S Milos, R Khazaee, LA McCaig… - … of Physiology-Lung …, 2017 - journals.physiology.org
Alterations to the pulmonary surfactant system have been observed consistently in
ventilation-induced lung injury (VILI) including composition changes and impairments in the …

[HTML][HTML] Understanding the mechanisms of ventilator-induced lung injury using animal models

PL Silva, M Scharffenberg, PRM Rocco - Intensive Care Medicine …, 2023 - Springer
Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas
exchange and providing rest to the respiratory muscles. However, mechanical ventilation …