An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer's Disease

T Numakawa, R Kajihara - International Journal of Molecular Sciences, 2024 - mdpi.com
Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple
roles in various aspects of neurons, including cell survival and synaptic function. BDNF and …

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

T Numakawa, R Kajihara - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system

T Numakawa, N Adachi, M Richards, S Chiba… - Neuroscience, 2013 - Elsevier
Brain-derived neurotrophic factor (BDNF) has multiple roles in the central nervous system
(CNS), including maintaining cell survival and regulation of synaptic function. In CNS …

[HTML][HTML] Functional interactions between steroid hormones and neurotrophin BDNF

T Numakawa, D Yokomaku, M Richards… - World Journal of …, 2010 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF), a critical neurotrophin, regulates many neuronal
aspects including cell differentiation, cell survival, neurotransmission, and synaptic plasticity …

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells

H Chen, M Lombès, D Le Menuet - Molecular brain, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal
growth, survival, synaptic plasticity and memorization. Altered expression levels are …

Actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2017 - mdpi.com
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including
mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for …

Recent advances in the crosstalk between the brain-derived neurotrophic factor and glucocorticoids

A Tsimpolis, K Kalafatakis… - Frontiers in …, 2024 - frontiersin.org
Brain-derived neurotrophic factor (BDNF), a key neurotrophin within the brain, by selectively
activating the TrkB receptor, exerts multimodal effects on neurodevelopment, synaptic …

Stress-induced depression and Alzheimer's disease: focus on astrocytes

OV Dolotov, LS Inozemtseva, NF Myasoedov… - International journal of …, 2022 - mdpi.com
Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter

T Numakawa, E Kumamaru, N Adachi… - Proceedings of the …, 2009 - National Acad Sciences
An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived
neurotrophic factor) are supposed to be involved in the pathophysiology of depressive …

Early life stress effects on glucocorticoid—BDNF interplay in the hippocampus

NP Daskalakis, ER De Kloet, R Yehuda… - Frontiers in molecular …, 2015 - frontiersin.org
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …