An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer's Disease
T Numakawa, R Kajihara - International Journal of Molecular Sciences, 2024 - mdpi.com
Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple
roles in various aspects of neurons, including cell survival and synaptic function. BDNF and …
roles in various aspects of neurons, including cell survival and synaptic function. BDNF and …
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
T Numakawa, R Kajihara - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …
Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system
T Numakawa, N Adachi, M Richards, S Chiba… - Neuroscience, 2013 - Elsevier
Brain-derived neurotrophic factor (BDNF) has multiple roles in the central nervous system
(CNS), including maintaining cell survival and regulation of synaptic function. In CNS …
(CNS), including maintaining cell survival and regulation of synaptic function. In CNS …
[HTML][HTML] Functional interactions between steroid hormones and neurotrophin BDNF
T Numakawa, D Yokomaku, M Richards… - World Journal of …, 2010 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF), a critical neurotrophin, regulates many neuronal
aspects including cell differentiation, cell survival, neurotransmission, and synaptic plasticity …
aspects including cell differentiation, cell survival, neurotransmission, and synaptic plasticity …
Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells
H Chen, M Lombès, D Le Menuet - Molecular brain, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal
growth, survival, synaptic plasticity and memorization. Altered expression levels are …
growth, survival, synaptic plasticity and memorization. Altered expression levels are …
Actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis
T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2017 - mdpi.com
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including
mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for …
mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for …
Recent advances in the crosstalk between the brain-derived neurotrophic factor and glucocorticoids
A Tsimpolis, K Kalafatakis… - Frontiers in …, 2024 - frontiersin.org
Brain-derived neurotrophic factor (BDNF), a key neurotrophin within the brain, by selectively
activating the TrkB receptor, exerts multimodal effects on neurodevelopment, synaptic …
activating the TrkB receptor, exerts multimodal effects on neurodevelopment, synaptic …
Stress-induced depression and Alzheimer's disease: focus on astrocytes
OV Dolotov, LS Inozemtseva, NF Myasoedov… - International journal of …, 2022 - mdpi.com
Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …
Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter
T Numakawa, E Kumamaru, N Adachi… - Proceedings of the …, 2009 - National Acad Sciences
An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived
neurotrophic factor) are supposed to be involved in the pathophysiology of depressive …
neurotrophic factor) are supposed to be involved in the pathophysiology of depressive …
Early life stress effects on glucocorticoid—BDNF interplay in the hippocampus
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …