The article by Goronzy et al.( 6) addresses the paradox of an age-dependent decline in
immune responses while autoimmune diseases increase in incidence. The authors …

Immunosenescence is the term commonly used to describe the multifaceted phenomenon
encompassing all changes occurring in the immune system during aging. It contributes to …

Immunosenescence contributes to render older adults more susceptible to pathogens and to
develop main age-related diseases. With the ever-increasing rise in the number and …

The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

T cells are a critical component of the immune system and required for protection against
viral and bacterial infections. However, the capacity of these cells to provide sufficient …

Aging represents a paradox of immunodeficiency and inflammation (inflamm-aging) and
autoimmunity (1). Over the lifespan there are changes in the architecture and functioning of …

Immune aging is best known for its immune defects that increase susceptibility to infections
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …

Prolonged life expectancy in the 20th century has been one of humankind's greatest
triumphs. However, the substantial increase in the human life span has ushered in a new …

Average life expectancy is continuously rising in all developed countries, leading to an ever-
increasing elderly population. Of the many functions of the body affected by the complex …

Higher morbidity and mortality following infections, particularly influenza, is observed in the
elderly population. Because of this, people over 65 years old are often targeted for …