Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

I Jochmans, A Brat, L Davies, HS Hofker… - The Lancet, 2020 - thelancet.com
Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …

Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant: a randomized clinical trial

P Husen, C Boffa, I Jochmans, C Krikke, L Davies… - JAMA …, 2021 - jamanetwork.com
Importance Continuous hypothermic machine perfusion during organ preservation has a
beneficial effect on graft function and survival in kidney transplant when compared with static …

The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys

J Kox, C Moers, D Monbaliu, A Strelniece… - …, 2018 - journals.lww.com
Background Hypothermic machine perfusion (HMP) of deceased donor kidneys is
associated with better outcome when compared to static cold storage (CS). Nevertheless …

Effects of oxygen during long-term hypothermic machine perfusion in a porcine model of kidney donation after circulatory death

LH Venema, A Brat, C Moers, NA't Hart, RJ Ploeg… - …, 2019 - journals.lww.com
Background. Hypothermic machine perfusion (HMP) has become standard care in many
center's to preserve kidneys donated after circulatory death (DCD). Despite a significant …

Improved kidney graft function after preservation using a novel hypothermic machine perfusion device

MHJ Maathuis, S Manekeller, A van der Plaats… - Annals of …, 2007 - journals.lww.com
Objective: To study graft function and ischemia/reperfusion injury of porcine kidneys after
preservation with the new Groningen Machine Perfusion (GMP) system versus static cold …

Short, cool, and well oxygenated–HOPE for kidney transplantation in a rodent model

P Kron, A Schlegel, O de Rougemont… - Annals of …, 2016 - journals.lww.com
Objectives: The aim of this study was to investigate novel and easily applicable preservation
perfusion techniques in kidney grafts obtained from donors after circulatory death (DCD) …

Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial

SA Hosgood, CJ Callaghan, CH Wilson, L Smith… - Nature medicine, 2023 - nature.com
Kidney transplantation is the optimal treatment for end-stage renal disease, but it is still
severely limited by a lack of suitable organ donors. Kidneys from donation after circulatory …

Normothermic ex vivo kidney perfusion improves early DCD graft function compared with hypothermic machine perfusion and static cold storage

P Urbanellis, M Hamar, JM Kaths, D Kollmann… - …, 2020 - journals.lww.com
Background. Better preservation strategies for the storage of donation after circulatory death
grafts are essential to improve graft function and to increase the kidney donor pool. We …

Hypothermic machine perfusion of kidneys retrieved from standard and high‐risk donors

I Jochmans, JM O'Callaghan, J Pirenne… - Transplant …, 2015 - Wiley Online Library
Hypothermic machine perfusion (HMP) of kidneys is a long‐established alternative to static
cold storage and has been suggested to be a better preservation method. Today, as our …

Benefits of active oxygenation during hypothermic machine perfusion of kidneys in a preclinical model of deceased after cardiac death donors

R Thuillier, G Allain, O Celhay, W Hebrard… - Journal of Surgical …, 2013 - Elsevier
Background Deceased after cardiac death donors (DCDs) represent a valuable source of
organs; however, preventing poor outcome is difficult, even with the use of machine …