Background: Medical evidence collected from new observational studies can sometimes
significantly alter our understanding of disease incidence and progression. This requires …

Background Medical evidence from more recent observational studies may significantly alter
our understanding of disease incidence and progression, and would require recalibration of …

Colorectal cancer is the fourth most common cancer and the second leading cause of
cancer death in the United States. Incidence and mortality from the disease have fallen over …

Background. As the complexity of microsimulation models increases, concerns about model
transparency are heightened. Methods. The authors conducted model “experiments” to …

Background. Existing colorectal cancer (CRC) screening models mostly focus on the
adenoma pathway of CRC development, overlooking the serrated neoplasia pathway, which …

The incidence of colorectal cancer diagnosed before age 50, often referred to as early-onset
colorectal cancer, has been increasing, whereas the overall colorectal cancer incidence has …

Background Microsimulation models of colorectal cancer (CRC) have helped inform national
screening guidelines and health policy decision-making. However, detailed descriptions of …

Simulation models provide a powerful tool for analyzing real-world systems. These models
are driven by input data, so when inputs are unknown and no data exists, the development …

Despite advances in the modeling and understanding of colorectal cancer development, the
dynamics of the progression from benign adenomatous polyp to colorectal carcinoma are …

Several lines of evidence support the premise that screening colonoscopy reduces
colorectal cancer (CRC) incidence, but there may be differential benefits for right-and left …