Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

Y Du, X Li, C Su, M Xi, X Zhang, Z Jiang… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose The gut microbial metabolite butyrate is linked to the modulation
of metabolic disease. The mechanism by which butyrate effects in atherosclerosis is …

Butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet

F Gao, YW Lv, J Long, JM Chen, J He… - Frontiers in …, 2019 - frontiersin.org
Background: Metabolic syndrome (MS) is one of the major causes of coronary artery
diseases (CAD). Gut microbiome diversity and its natural fermentation products are not only …

[HTML][HTML] Role of butyrate, a gut microbiota derived metabolite, in cardiovascular diseases: A comprehensive narrative review

P Amiri, SA Hosseini, S Ghaffari, H Tutunchi… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases (CVD) are major causes of death worldwide. Recently, new roles
for intestinal microbiota in pathology and treatment of CVD have been proposed. Butyrate, a …

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

SC Bridgeman, W Northrop, PE Melton… - Pharmacological …, 2020 - Elsevier
Metabolic syndrome (MetS) and the associated incidence of cardiovascular disease and
type 2 diabetes represents a significant contributor to morbidity and mortality worldwide …

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

VA Matheus, LCS Monteiro… - Experimental …, 2017 - journals.sagepub.com
In this study, we investigated the effect of diet supplementation with sodium butyrate (5%
w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters …

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

EC Aguilar, AJ Leonel, LG Teixeira, AR Silva… - Nutrition, Metabolism …, 2014 - Elsevier
Background & aims Butyrate is a four-carbon fatty acid that presents anti-inflammatory, anti-
oxidative and apoptotic properties in colon and several cell lines. Because atherosclerosis …

Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice

S Zhai, S Qin, L Li, L Zhu, Z Zou… - FEMS microbiology …, 2019 - academic.oup.com
Butyrate, a key metabolite fermented by gut microbiota mainly from undigested
carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms …

Protective role of butyrate in obesity and diabetes: New insights

A Mayorga-Ramos, C Barba-Ostria… - Frontiers in …, 2022 - frontiersin.org
Studies in human microbiota dysbiosis have shown that short-chain fatty acids (SCFAs) like
propionate, acetate, and particularly butyrate, positively affect energy homeostasis …

The protective role of butyrate against obesity and obesity-related diseases

S Coppola, C Avagliano, A Calignano, R Berni Canani - Molecules, 2021 - mdpi.com
Worldwide obesity is a public health concern that has reached pandemic levels. Obesity is
the major predisposing factor to comorbidities, including type 2 diabetes, cardiovascular …

Is butyrate the link between diet, intestinal microbiota and obesity‐related metabolic diseases?

LK Brahe, A Astrup, LH Larsen - Obesity reviews, 2013 - Wiley Online Library
It is increasingly recognized that there is a connection between diet, intestinal microbiota,
intestinal barrier function and the low‐grade inflammation that characterizes the progression …