Rationale Obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular
disease. Continuous positive airway pressure (CPAP) delivered via a nasal mask during …

Abstract The Sleep Apnea cardioVascular Endpoints (SAVE) study is an ongoing
investigator-initiated and conducted, international, multicenter, open, blinded endpoint …

Background and Purpose Obstructive sleep apnea (OSA) has been shown to increase the
risk of stroke. Although continuous positive airway pressure (CPAP) is considered the …

Purpose The associations between obstructive sleep apnea (OSA) and all-cause and
cardiovascular mortality are well established but are not entirely consistent. To accurately …

Abstract Study Objectives Randomized controlled trials (RCTs) have shown no reduction in
adverse cardiovascular (CV) events in patients randomized to continuous positive airway …

Statistical analysis plan for the Sleep Apnea cardioVascular Endpoints study: An
international randomised controlled trial to determine whether continuous positive airways …

Background: Obstructive sleep apnoea (OSA) is highly prevalent and significantly
associated with major adverse cardiovascular events (MACEs). Continuous positive airway …

Aims To assess whether continuous positive airway pressure (CPAP) therapy reduces major
adverse cardiovascular events (MACE) in patients with moderate-to-severe obstructive …

Background Obstructive sleep apnea is associated with an increased risk of cardiovascular
events; whether treatment with continuous positive airway pressure (CPAP) prevents major …

Background It remains uncertain whether continuous positive airway pressure (CPAP)
therapy would significantly impact hard clinical outcomes in patients with obstructive sleep …