Inflammation is strictly interconnected to anti-inflammatory mechanisms to maintain tissue
homeostasis. The disruption of immune homeostasis can lead to acute and chronic …

Fragile skin and susceptibility to skin tearing are major problems among the elderly and can
be complicated further by impaired wound healing. Non-healing wounds fail to progress …

Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury,
inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated …

Objective Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-
mediated target cell apoptosis. However, during inflammation, GrB accumulates in the …

Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are
traditionally considered to cause apoptosis in tumor cells and virally infected cells. However …

Simple Summary Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic
T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its …

Chronic inflammation and impaired wound healing play important roles in the
pathophysiology of cardiovascular diseases. Moreover, the aberrant secretion of proteases …

Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected
with intracellular pathogens. One mechanism, known as granule exocytosis, employs the …

Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has
a high mortality and is responsible for huge health expenditure. The pathophysiology of …

The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as a primary
mechanism that is used by cytotoxic lymphocytes to eliminate allogeneic, virally infected …