Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is
involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and …

To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …

Background Cross-presentation by dendritic cells (DCs) is a crucial prerequisite for effective
priming of cytotoxic T-cell responses against bacterial, viral and tumor antigens; however …

Summary MHC class I (MHC‐I) molecules are the centerpieces of cross‐presentation. They
are loaded with peptides derived from exogenous sources and displayed on the plasma …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display
peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells. Like …

T lymphocytes recognize peptide antigens presented by class I and class II molecules
encoded by the major histocompatibility complex (MHC). Classical antigen-presentation …

Highlights•Cross-presentation is important for cellular immunity against pathogens and
cancer.•Biomimetic vaccines can be designed to enhance antigen presentation on MHC …

Dendritic cells (DCs) can present extracellularly derived antigens in the context of major
histocompatibility complex (MHC) class I molecules, a process called cross-presentation …