Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …

In order for cytotoxic T cells to initiate immune responses, peptides derived from internalized
antigens must be presented to the cytotoxic T cells on major histocompatibility complex …

Initiation of cell-mediated immune responses requires processing of intracellular pathogens
into peptide fragments and presentation of these fragments to effector T cells. In the past few …

Dendritic cells (DCs) are crucial for priming of naive CD8+ T lymphocytes to exogenous
antigens, so-called “cross-priming.” We report that exogenous protein antigen can be …

The transfer of membrane proteins from APC to T cells was initially described in the 1970s,
and subsequent work has described two mechanisms of transfer: APC-derived exosomes …

The MHC class I pathway is usually fueled by endogenous Ags, while exogenous Ags reach
the MHC class II pathway. Although exogenous epitopes may also enter the MHC class I …

Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to
present them on MHC class I molecules to antigen-specific CD8+ T lymphocytes after …

MHC–peptide complexes mediate key functions in adaptive immunity. In a classical view,
MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II …

The concept of distinct endogenous and exogenous pathways for generating peptides for
MHC‐I and MHC‐II‐restricted presemation to CD4+ or CD8+ T cells fits well with the bulk of …

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …