Over the past year, several important advances have been made in understanding the
mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside …

Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has
long focused on their extreme polymorphism. These molecules present peptides to T cells …

Defective ribosomal products provide an important supply of endogenous peptides for entry
into the classic MHC class I antigen presentation pathway. The recruitment of endoplasmic …

Tumor cells that constitutively express MHC class I molecules and are genetically modified
to express MHC class II (MHC II) and costimulatory molecules are immunogenic and have …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

In dendritic cells (DCs), peptides derived from internalized particulate substrates are
efficiently cross-presented by major histocompatibility complex (MHC) class I molecules …

Abstract Interleukin-10 (IL-10) inhibits antigen-specific T cell responses when human
monocytes are used as antigen-presenting cells. This is correlated with a down-regulation of …

Antigen cross-presentation describes the process through which dendritic cells (DCs)
acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Cross‐presentation involves the uptake and processing of exogenous antigens within the
major histocompatibility complex (MHC) class I pathway. This process is primarily performed …