Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease
Y Zhang, G Reif, DP Wallace - Cellular signalling, 2020 - Elsevier
In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease
A Raman, GA Reif, Y Dai, A Khanna, X Li… - Journal of the …, 2017 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …
Inflammation and fibrosis in polycystic kidney disease
CJ Song, KA Zimmerman, SJ Henke… - Kidney Development and …, 2017 - Springer
Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst
formation and fibrosis (Wilson, N Engl J Med 350: 151–164, 2004) and is caused by …
formation and fibrosis (Wilson, N Engl J Med 350: 151–164, 2004) and is caused by …
Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation?
JP Calvet - Kidney international, 1993 - Elsevier
Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular
differentiation? Polycystic kidney disease (PKD) is inherited as a dominant or recessive trait …
differentiation? Polycystic kidney disease (PKD) is inherited as a dominant or recessive trait …
Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1
K Lee, S Boctor, LMC Barisoni… - Journal of the American …, 2015 - journals.lww.com
Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
β4 integrin and laminin 5 are aberrantly expressed in polycystic kidney disease: role in increased cell adhesion and migration
D Joly, V Morel, A Hummel, A Ruello… - The American journal of …, 2003 - Elsevier
Extracellular matrix alterations have been suggested to be part of the early events occurring
in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a disease characterized by …
in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a disease characterized by …
Aberrant epithelial cell growth in autosomal dominant polycystic kidney disease
PD Wilson - American journal of kidney diseases, 1991 - Elsevier
Renal cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is
characterized by increased epithelial cell proliferation and fluid accumulation. Using …
characterized by increased epithelial cell proliferation and fluid accumulation. Using …
Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease
In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease
B Liu, C Li, Z Liu, Z Dai, Y Tao - BMC nephrology, 2012 - Springer
Abstract Background Polycystic Kidney Disease (PKD) kidneys exhibit increased
extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We …
extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We …
The controversial role of fibrosis in autosomal dominant polycystic kidney disease
M Fragiadaki, FM Macleod, ACM Ong - International Journal of Molecular …, 2020 - mdpi.com
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the
progressive growth of cysts but it is also accompanied by diffuse tissue scarring or fibrosis. A …
progressive growth of cysts but it is also accompanied by diffuse tissue scarring or fibrosis. A …
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