When nanotechnology meets the ocular surface

C Bucolo, A Maltese, F Drago - Expert Review of Ophthalmology, 2008 - Taylor & Francis
Controlled and sustained delivery of drugs for ophthalmic diseases continues to remain a
major challenge in the field of pharmaceutical drug delivery. To overcome the problems of …

Therapeutic implications of nanomedicine for ocular drug delivery

T Meng, V Kulkarni, R Simmers, V Brar, Q Xu - Drug discovery today, 2019 - Elsevier
Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of
eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; …

Emerging nano-formulations and nanomedicines applications for ocular drug delivery

D Khiev, ZA Mohamed, R Vichare, R Paulson, S Bhatia… - Nanomaterials, 2021 - mdpi.com
Ocular diseases can deteriorate vision to the point of blindness and thus can have a major
impact on the daily life of an individual. Conventional therapies are unable to provide …

Nanoparticles for drug delivery to the anterior segment of the eye

DR Janagam, L Wu, TL Lowe - Advanced drug delivery reviews, 2017 - Elsevier
Commercially available ocular drug delivery systems are effective but less efficacious to
manage diseases/disorders of the anterior segment of the eye. Recent advances in …

Recent advances in topical nano drug-delivery systems for the anterior ocular segment

P Lakhani, A Patil, S Majumdar - Therapeutic delivery, 2018 - Taylor & Francis
Over the past decade, there has been a rise in the number of clinical cases of moderate to
severe anterior segment ocular diseases. Conventional topical ophthalmic formulations …

Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases

Y Su, X Fan, Y Pang - Biomaterials Science, 2023 - pubs.rsc.org
Numerous novel nano-based ocular drug delivery systems have been developed to
overcome the limitations of conventional drug delivery systems, which have demonstrated …

Nanotherapies for the treatment of ocular diseases

S Reimondez-Troitiño, N Csaba, MJ Alonso… - European Journal of …, 2015 - Elsevier
The topical route is the most frequent and preferred way to deliver drugs to the eye.
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …

Drug delivery to the eye: what benefits do nanocarriers offer?

RR Joseph, SS Venkatraman - Nanomedicine, 2017 - Taylor & Francis
Ocular drug delivery has seen several advances in the past few decades, with respect to
new drugs, improved formulations, targeted delivery, as well as exploration of new routes of …

Polymeric nanoparticles for ophthalmic drug delivery: an update on research and patenting activity

S HS Boddu - Recent patents on Nanomedicine, 2012 - ingentaconnect.com
Despite intense research efforts; effective delivery of drugs to the eye remains an enormous
challenge. The eye is a unique organ with complex structure and functions. It is protected by …

An overview on pharmacokinetics, disposition, and safety of nanoparticles in ocular applications

X Li, L Li, Z Zhang, H Chen - Current drug metabolism, 2013 - ingentaconnect.com
In the past three decades, the application of nanotechnology in ophthalmology has gained
considerable progress for the treatment of ocular diseases including anterior and posterior …