Stroke causes brain injury with neuroinflammation which exacerbates the neuronal damage.
Recent studies show that anti-inflammatory cytokine interleukin-19 (IL-19) plays a critical …

Objective Inflammation and immune responses are crucial factors associated with the onset
and progression of stroke. Interleukin-11 (IL-11) is a hematopoietic IL-6 family cytokine that …

Background Interleukin-35 (IL-35), an anti-inflammatory and antioxidant cytokine, plays a
potent immunosuppressive role in various diseases. However, the effects of IL-35 on blood …

Abstract Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family which
is upregulated after cerebral ischemia. The functional role of IL-18 in cerebral ischemia is …

We previously reported that the levels of astrocyte-derived interleukin-17A (IL-17A)
increased both in the peri-infarct region and cerebrospinal fluid (CSF) of mice with 1-h …

Acute ischemic stroke is followed by a complex interplay between the brain and the immune
system in which ischemia-reperfusion leads to a detrimental inflammatory response that …

Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells
are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent …

Abstract Background Interleukin-23 (IL-23) is required for T helper 17 (Th17) cell responses
and IL-17 production in ischemic stroke. We previously showed that the IL-23/IL-17 axis …

Ischemic stroke causes brain injury with activation of an inflammatory response that can
contribute to clinical impairment. As a novel cytokine of the interleukin-1 (IL-1) family, IL-33 …

IL-35 has been identified as a novel anti-inflammatory cytokine that belongs to the IL-12
cytokine family and has been verified to play a protective role in autoimmune diseases. In …