[HTML][HTML] Perampanel in real-world clinical care of adolescent and adult patients with epilepsy: Results from the retrospective Phase IV PROVE Study

E Segal, J Wheless, K Moretz, P Penovich, A Patten… - Seizure, 2022 - Elsevier
Purpose Report final data from adolescent (12–< 18 years) and adult (≥ 18 years) patients
from PROVE (NCT03208660), a multicenter, retrospective, non-interventional, Phase IV …

Clinical experience with perampanel for refractory pediatric epilepsy in one Canadian center

AN Datta, Q Xu, S Sachedina… - Journal of Child …, 2017 - journals.sagepub.com
Perampanel (PER) is a new antiseizure medication that inhibits the α-amino-3-hydroxy-5-
methyl-4-isoxazole-propionic acid (AMPA) class of glutamate receptors. It is important for …

[HTML][HTML] The impact of perampanel on cognition: a systematic review of studies employing standardized tests in patients with epilepsy

JA Witt, C Helmstaedter - Seizure, 2022 - Elsevier
This systematic review was conducted to reveal the cognitive effects of perampanel (PER)
as assessed by objective standardized neuropsychological measures in patients with …

[HTML][HTML] Perampanel monotherapy for the treatment of epilepsy: clinical trial and real-world evidence

T Yamamoto, A Gil-Nagel, JW Wheless, JH Kim… - Epilepsy & Behavior, 2022 - Elsevier
Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid receptor antagonist, is a once-daily oral anti-seizure medication (ASM) for focal-onset …

Profile of perampanel and its potential in the treatment of partial onset seizures

S Rheims, P Ryvlin - Neuropsychiatric Disease and Treatment, 2013 - Taylor & Francis
Perampanel (PER) is a novel antiepileptic compound that decreases neuronal excitability by
modulating glutamatergic transmission through selective noncompetitive blockade of AMPA …

Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability

A Schulze-Bonhage, M Hintz - Patient preference and adherence, 2015 - Taylor & Francis
Perampanel (PER) is a novel antiepileptic drug recently introduced for the adjunctive
treatment in epilepsy patients aged 12 years or older with partial-onset seizures with or …

Two-year real-world experience with perampanel in patients with refractory focal epilepsy: Austrian data

A Rohracher, G Kalss, M Leitinger… - Therapeutic …, 2016 - journals.sagepub.com
Background: The aim of this study was to analyse registry data of seizure outcome and
adverse events (AEs) for perampanel as add-on therapy in patients with focal epilepsy since …

[HTML][HTML] Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4–19 years with epilepsy: a real-world study

SE Youn, HC Kang, JS Lee, HD Kim, SH Kim - Scientific Reports, 2023 - nature.com
This study determined the 24-month outcomes of perampanel treatment in children and
adolescents with epilepsy. The percentage of≥ 50% responders was 47.3%(139/294) at 12 …

[HTML][HTML] Effectiveness, safety and tolerability of perampanel by age group when used to treat people with focal and generalized epilepsy in clinical practice: The …

J Wheless, RT Wechsler, P Penovich, E Segal… - Epilepsy & Behavior, 2023 - Elsevier
Objective To assess the effectiveness and safety/tolerability of perampanel (PER) in people
with epilepsy (PWE) treated in everyday clinical practice for focal and generalized seizures …

Perampanel in routine clinical use in idiopathic generalized epilepsy: the 12‐month GENERAL study

V Villanueva, J Montoya, A Castillo… - …, 2018 - Wiley Online Library
Objective To analyze the effectiveness and tolerability of perampanel across different
seizure types in routine clinical care of patients with idiopathic generalized epilepsy (IGE) …