Alzheimer's disease (AD) is one of the major life-threatening diseases for the elderly
because neither pathogenesis nor effective treatment is available. Mitochondrial aldehyde …

Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic
aldehydes, including 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxides, are …

Abstract Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in
acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of …

Aldehydes-induced toxicity has been implicated in many neurodegenerative diseases.
Exposure to reactive aldehydes from (1) alcohol and food metabolism;(2) environmental …

Growing body of evidence suggests that mitochondrial dysfunctions and resultant oxidative
stress are likely responsible for many neurodegenerative diseases, including Alzheimer's …

Hydroxynonenal (4HNE) is a toxic aldehyde which can accumulate during
neurodegenerative diseases, such as AD. 4HNE-induced neuronal cytotoxicity includes the …

Past studies have indicated that the dysregulation of Aldehyde dehydrogenase 2 (ALDH2) is
related to the pathogenesis of acute stroke. However, the underlying mechanisms of ALDH2 …

Research, an association between ex-pression of mitochondrial aldehyde dehydrogenase
(ALDH2), a mitochondrial chaperon expressed in the brain, and the prevalence of stroke is …

For decades, it has been acknowledged that oxidative stress due to free radical species
contributes to the pathophysiology of aging and neurodegenerative diseases. Aldehyde …

Alzheimer's disease (AD) is associated with high incidence of cardiovascular events but the
mechanism remains elusive. Our previous study reveals a tight correlation between cardiac …