New immunological approaches and cytokine targets in asthma and allergy

RG Stirling, KF Chung - European Respiratory Journal, 2000 - Eur Respiratory Soc
The aims of current asthma treatment are to suppress airway inflammation and control
symptoms, and corticosteroids maintain a commanding position in this role. Steroids …

An update on emerging drugs for asthma

GM Walsh - Expert Opinion on Emerging Drugs, 2012 - Taylor & Francis
Introduction: It is recognized that airway inflammation is key to asthma pathogenesis.
Biopharmaceutical approaches have identified new therapies that target key cells and …

[HTML][HTML] Type 2 inflammation and biological therapies in asthma: Targeted medicine taking flight

I Howell, A Howell, ID Pavord - Journal of Experimental Medicine, 2023 - rupress.org
The field of asthma has undergone a dramatic change in recent years. Advances in our
understanding of type 2 airway inflammation have driven the discovery of monoclonal …

New Anti-inflammatory Drugs for COPD: Is There a Possibility of Developing Drugs That Can Fundamentally Suppress Inflammation?

Y Yamauchi, T Nagase - Chronic Obstructive Pulmonary Disease: A …, 2017 - Springer
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow
limitation that is usually progressive and associated with chronic inflammation of the …

[HTML][HTML] Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases

J Garth, JW Barnes, S Krick - International journal of molecular sciences, 2018 - mdpi.com
Cytokines are key players in the initiation and propagation of inflammation in chronic
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …

Potential novel therapies for chronic obstructive pulmonary disease

PJ Barnes - … to Treatment: Novartis Foundation Symposium 234, 2000 - Wiley Online Library
While considerable progress has been made in development of drugs for asthma, there
have been few advances in the treatment of chronic obstructive pulmonary disease (COPD) …

Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD

JB Morjaria, M Malerba, R Polosa - Drug Discovery Today, 2010 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition
with declining lung function associated with airway inflammation, mucus hypersecretion and …

Immunology of asthma and chronic obstructive pulmonary disease

PJ Barnes - Nature Reviews Immunology, 2008 - nature.com
Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway
diseases that involve chronic inflammation of the respiratory tract, but the type of …

Cytokine modulators as novel therapies for asthma

PJ Barnes - Annual review of pharmacology and toxicology, 2002 - annualreviews.org
Cytokines play a critical role in orchestrating and perpetuating inflammation in asthmatic
airways and several specific cytokine and chemokine inhibitors are now in development for …

Current and emerging nonsteroidal anti-inflammatory therapies targeting specific mechanisms in asthma and allergy

L Bjermer, Z Diamant - Treatments in respiratory medicine, 2004 - Springer
Today inhaled corticosteroids (ICS) are regarded as the first-line controller anti-inflammatory
treatment in the management of asthma. However, there is an increasing awareness of the …