The biologic nature of COPD inflammation is not well understood and agents that inhibit
inflammation in COPD are a major unmet need. However, a variety of agents that have the …

Kinases are believed to play a crucial role in the expression and activation of inflammatory
mediators in the airway, in T-cell function, and in airway remodeling. Important pro …

The striking clinical results from recent studies with Remicade®(infliximab, a monoclonal
anti-TNFα antibody) in rheumatoid arthritis, Crohn's disease and psoriasis demonstrate the …

Guidelines for the management of obstructive airway diseases do not emphasize the
measurement of bronchitis to indicate appropriate treatments or monitor response to …

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Various cytokines play a critical role in pathophysiology of chronic inflammatory lung
diseases including asthma and chronic obstructive pulmonary disease (COPD). The …

New studies of chronic obstructive pulmonary disease (COPD) are revealing the key role of
airway epithelial cells and innate immune cells in the initiation, exacerbation, and …

Biological drugs are approved to treat patients with severe uncontrolled asthma and are
directed against mediators of type 2 immunity. These agents are effective in reducing the risk …

Asthma is a common disease with an increasing prevalence worldwide. Up to 10% of these
patients have asthma that is refractory to current therapy. This group have a disproportionate …

Chronic obstructive pulmonary disease (COPD) is caused by the chronic inhalation of toxic
particles and gases that are primarily but not exclusively derived from cigarette smoke that …