Background: Postzygotic chromosomal variation in neuronal cells is hypothesized to make a
substantial contribution to the etiology and pathogenesis of neuropsychiatric disorders …

OBJECTIVE: Genetic instability manifested as loss or gain of whole chromosomes
(aneuploidy) is a newly described feature of the human brain. Aneuploidy in the brain was …

It is hard to believe that all the cells of a human brain share identical genomes. Indeed,
single cell genetic studies have demonstrated intercellular genomic variability in the normal …

Background Cytogenomic mutations and chromosomal abnormality are implicated in the
neuropathology of several brain diseases. Cell heterogeneity of brain tissues makes their …

Aim Experimental verification of the hypothesis about the possible involvement of the mosaic
genome variations (mosaic aneuploidy) in the pathogenesis of a number of mental illnesses …

Somatic mutations occur after the formation of the zygote, reflecting random mutations
during normal mitotic cell divisions of embryonic development, and are hence present in …

Background Understanding the mechanisms underlying generation of neuronal variability
and complexity remains the central challenge for neuroscience. Structural variation in the …

Recent reports suggest that somatic structural changes occur in the human genome, but
how these genomic alterations might contribute to disease is unknown. Using samples …

Every cell in the human brain possesses a unique genome that is the product of the
accumulation of somatic mutations starting from the first postzygotic cell division and …

Genomic or chromosomal mosaicism in human brain cells is considered a source for
neuronal diversity and a mechanism for neuropsychiatric diseases. However, there is still a …