Physiological and Metabolic Consequence of Fetal Hyperglycemia Using the Zebrafish Model
BD Konadu - 2023 - search.proquest.com
Fetal Hyperglycemia (FH), arising from high maternal glucose levels during Gestational
Diabetes Mellitus (GDM), has emerged as a pivotal factor in the development of adult …
Diabetes Mellitus (GDM), has emerged as a pivotal factor in the development of adult …
Fetal hyperglycemia and the origin of adult obesity
Fetal Hyperglycemia (FH) plays a critical role in adult obesity. FH occurs upon fetal exposure
to high maternal glucose during Gestational Diabetes, resulting in hyperinsulinemia and …
to high maternal glucose during Gestational Diabetes, resulting in hyperinsulinemia and …
Zebrafish model of in utero glucose exposure alters developmental programming that leads to life‐long metabolic consequences
Background and Aim One in ten pregnancies in the US, suffers from Gestational Diabetes
Mellitus (GDM). Offspring born to mothers who have GDM have a higher risk of developing …
Mellitus (GDM). Offspring born to mothers who have GDM have a higher risk of developing …
Zebrafish model of Gestational Diabetes
One in seven births in the US are affected by Gestational Diabetes Mellitus (GDM). In
addition to the acute risk of death and complications for the fetus, GDM exposure in utero …
addition to the acute risk of death and complications for the fetus, GDM exposure in utero …
OR24-5 Zebrafish in Utero Glucose Exposure Induces Lipid Dysregulation That Is Abrogated by Acetyl CoA Carboxylase or Glycolysis Inhibition
Abstract Background and Aim One in ten pregnancies suffer from Gestational Diabetes
Mellitus (GDM). GDM exposes fetus to high uterine glucose that causes fetal hyperglycemia …
Mellitus (GDM). GDM exposes fetus to high uterine glucose that causes fetal hyperglycemia …
Mild gestational hyperglycemia in rat induces fetal overgrowth and modulates placental growth factors and nutrient transporters expression
O Cisse, I Fajardy, A Dickes-Coopman, E Moitrot… - Plos one, 2013 - journals.plos.org
Mild gestational hyperglycemia is often associated with fetal overgrowth that can predispose
the offspring to metabolic diseases later in life. We hypothesized that unfavorable …
the offspring to metabolic diseases later in life. We hypothesized that unfavorable …
Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model
Hyperglycaemia in pregnancy (HIP) is a pregnancy complication characterized by mild to
moderate hyperglycaemia that negatively impacts short‐and long‐term health of mother and …
moderate hyperglycaemia that negatively impacts short‐and long‐term health of mother and …
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
B Shashikadze, L Valla, SD Lombardo, C Prehn… - Molecular …, 2023 - Elsevier
Objective To gain mechanistic insights into adverse effects of maternal hyperglycemia on the
liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed …
liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed …
1176-P: Maternal Hyperglycemia Leads to Distinct Differences in Metabolism and Pancreatic Beta-Cell Function in Male and Female Offspring
Maternal hyperglycemia is a major risk factor for future T2D risk in the offspring. To better
understand T2D pathogenesis in this context, we used a mouse model of hyperglycemia …
understand T2D pathogenesis in this context, we used a mouse model of hyperglycemia …
Maternal obesity characterized by gestational diabetes increases the susceptibility of rat offspring to hepatic steatosis via a disrupted liver metabolome
TJ Pereira, MA Fonseca, KE Campbell… - The Journal of …, 2015 - Wiley Online Library
Key points Gestational diabetes mellitus is a common complication of pregnancy, but its
effects on the offspring are poorly understood. We developed a rat model of diet‐induced …
effects on the offspring are poorly understood. We developed a rat model of diet‐induced …