Purpose Neurocognitive impairment is a common and debilitating complication of sickle cell
disease (SCD) resulting from a combination of biological and environmental factors. The …

Background Vaso-occlusive pain episodes (VOEs) are the hallmark of sickle cell disease
(SCD), and our current understanding of disease biology, treatment, and psychological …

This study sought to link neurocognitive profiles in sickle cell disease (SCD) patients with
clinical characteristics. We conducted a prospective cohort study of adults with SCD who …

A previous exploratory analysis of a COMT gene single-nucleotide polymorphism (SNP) and
a DRD3 SNP by our group suggested possible contributions to pain-related acute care …

Introduction: Pain is a lifelong companion of individuals with sickle cell disease (SCD) and
has a severe impact on their quality of life. Both acute crisis pain and chronic non-crisis pain …

A chronic inflammatory state to a large extent explains sickle cell disease (SCD)
pathophysiology. Nonetheless, the principal dysregulated factors affecting this major …

Sickle cell disease (SCD) is the most common inherited single-gene disease. Complications
include chronic anaemia, reduced oxygen-carrying capability, and cerebral vasculopathy …

Objective The incidence and prevalence of cognitive decline and dementia are significantly
higher among African Americans compared with non-Hispanic Whites. The aim of this study …

Background Sickle cell anemia may be associated with cognitive dysfunction, and some
complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we …

Study objectives Compared to typically developing children and young adults (CYA-TD),
those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties …