Vα24-invariant natural killer T cells (NKTs) have anti-tumor properties that can be enhanced
by chimeric antigen receptors (CARs). Here we report updated interim results from the first-in …

Vα24-invariant natural killer T (NKT) cells have shown potent anti-tumor properties in murine
tumor models and have been linked to favorable outcomes in patients with cancer. However …

Purpose: Vα24-invariant natural killer T cells (NKT) are attractive carriers for chimeric
antigen receptors (CAR) due to their inherent antitumor properties and preferential …

The outcome of patients affected by high-risk or metastatic neuroblastoma (NB) remains
grim, with≥ 50% of the children experiencing relapse or progression of the disease despite …

Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-
generation chimeric antigen receptor (CAR) was safe, but the cells had poor expansion and …

Patients with high risk neuroblastoma have a poor prognosis and survivors are often left with
debilitating long term sequelae from treatment. Even after integration of anti-GD2 …

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …

Advances in the design of chimeric antigen receptors (CARs) have improved the antitumor
efficacy of redirected T cells. However, functional heterogeneity of CAR T cells limits their …

The reprogramming of a patient's immune system through genetic modification of the T cell
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …

We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2
antigen expressed by neuroblastoma tumor cells and treated patients with this disease. Two …