Concordance of Lumipulse cerebrospinal fluid t‐tau/Aβ42 ratio with amyloid PET status

J Kaplow, M Vandijck, J Gray, M Kanekiyo… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Cerebrospinal fluid (CSF) biomarkers can identify individuals with Alzheimer's
disease (AD) pathology (eg, amyloid plaques, neurofibrillary tangles), but defined analyte …

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays

A Keshavan, H Wellington, Z Chen… - Alzheimer's & …, 2021 - Wiley Online Library
INTRODUCTION We assessed the concordance of cerebrospinal fluid (CSF) amyloid beta
(Aβ) and tau measured on the fully automated Lumipulse platform with pre‐symptomatic …

[HTML][HTML] Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging

SE Schindler, JD Gray, BA Gordon, C Xiong… - Alzheimer's & …, 2018 - Elsevier
Introduction Levels of amyloid β peptide 42 (Aβ42), total tau, and phosphorylated tau-181
are well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, but …

Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse

D Alcolea, J Pegueroles, L Munoz… - Annals of clinical …, 2019 - Wiley Online Library
Objective To determine the cutoffs that optimized the agreement between 18F‐Florbetapir
positron emission tomography (PET) and Aβ1‐42, Aβ1‐40, tTau, pTau and their ratios …

Detection of Alzheimer's disease amyloid beta 1‐42, p‐tau, and t‐tau assays

AC van Harten, HJ Wiste, SD Weigand… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We aimed to provide cut points for the automated Elecsys Alzheimer's disease
(AD) cerebrospinal fluid (CSF) biomarkers. Methods Cut points for Elecsys amyloid beta 42 …

Nonlinear association between cerebrospinal fluid and florbetapir F-18 β-amyloid measures across the spectrum of Alzheimer disease

JB Toledo, M Bjerke, X Da, SM Landau… - JAMA …, 2015 - jamanetwork.com
Importance Cerebrospinal fluid (CSF) and positron emission tomographic (PET) amyloid
biomarkers have been proposed for the detection of Alzheimer disease (AD) pathology in …

Comparing CSF amyloid‐beta biomarker ratios for two automated immunoassays, Elecsys and Lumipulse, with amyloid PET status

EAJ Willemse, BM Tijms… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction We evaluated for two novel automated biomarker assays how cerebrospinal
fluid (CSF) amyloid beta (Aβ) 1–42‐ratios improved the concordance with amyloid positron …

Analytical and clinical performances of the automated Lumipulse cerebrospinal fluid Aβ42 and T-Tau assays for Alzheimer's disease diagnosis

JL Bayart, B Hanseeuw, A Ivanoiu, V Van Pesch - Journal of neurology, 2019 - Springer
Background Cerebrospinal fluid (CSF) biomarkers are increasingly used to diagnose
Alzheimer's disease (AD). However, important methodological and technical remain …

P‐tau/aβ42 and aβ42/40 ratios in csf are equally predictive of amyloid pet status

MR Campbell, S Ashrafzadeh‐Kian… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Measurement of amyloid beta (Aβ40 and Aβ42) and tau (phosphorylated tau [p‐
tau] and total tau [t‐tau]) in cerebrospinal fluid (CSF) can be utilized to differentiate clinical …

[HTML][HTML] Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease

EN Wilson, CB Young, J Ramos Benitez… - Alzheimer's Research & …, 2022 - Springer
Background The recent promise of disease-modifying therapies for Alzheimer's disease
(AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis …