Diagnostic accuracy of quantitative micro-elastography for margin assessment in breast-conserving surgery

KM Kennedy, R Zilkens, WM Allen, KY Foo, Q Fang… - Cancer research, 2020 - AACR
Inadequate margins in breast-conserving surgery (BCS) are associated with an increased
likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS …

Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery

P Gong, SL Chin, WM Allen, H Ballal, JD Anstie, L Chin… - Cancer Research, 2022 - AACR
Breast-conserving surgery (BCS) is commonly used for the treatment of early-stage breast
cancer. Following BCS, approximately 20% to 30% of patients require reexcision because …

Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

WM Allen, L Chin, P Wijesinghe, RW Kirk… - Biomedical optics …, 2016 - opg.optica.org
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with
typically 20-30% of cases requiring a second surgical procedure arising from postoperative …

Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

WM Allen, KY Foo, R Zilkens, KM Kennedy… - Biomedical optics …, 2018 - opg.optica.org
It has been demonstrated that optical coherence micro-elastography (OCME) provides
additional contrast of tumor compared to optical coherence tomography (OCT) alone …

Wide-field quantitative micro-elastography of human breast tissue

WM Allen, KM Kennedy, Q Fang, L Chin… - Biomedical Optics …, 2018 - opg.optica.org
Currently, 20-30% of patients undergoing breast-conserving surgery require a second
surgery due to insufficient surgical margins in the initial procedure. We have developed a …

Investigation of optical coherence microelastography as a method to visualize cancers in human breast tissue

BF Kennedy, RA McLaughlin, KM Kennedy, L Chin… - Cancer Research, 2015 - AACR
An accurate intraoperative identification of malignant tissue is a challenge in the surgical
management of breast cancer. Imaging techniques that help address this challenge could …

Simplifying the assessment of human breast cancer by mapping a micro‐scale heterogeneity index in optical coherence elastography

L Chin, B Latham, CM Saunders… - Journal of …, 2017 - Wiley Online Library
Surgical treatment of breast cancer aims to identify and remove all malignant tissue.
Intraoperative assessment of tumor margins is, however, not exact; thus, re‐excision is …

Intraoperative evaluation of breast tumor margins with optical coherence tomography

FT Nguyen, AM Zysk, EJ Chaney, JG Kotynek… - Cancer research, 2009 - AACR
As breast cancer screening rates increase, smaller and more numerous lesions are being
identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean …

Compression OCT-elastography combined with speckle-contrast analysis as an approach to the morphological assessment of breast cancer tissue

AA Plekhanov, EV Gubarkova, MA Sirotkina… - Biomedical Optics …, 2023 - opg.optica.org
Currently, optical biopsy technologies are being developed for rapid and label-free
visualization of biological tissue with micrometer-level resolution. They can play an …

Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography

H Schmidt, C Connolly, S Jaffer, T Oza… - The Breast …, 2020 - Wiley Online Library
Background Currently, positive margins at lumpectomy contribute to health care cost, patient
anxiety, and treatment delay. Multiple technology solutions are being explored with the aim …